Microdosing For Depression Appears To Work About As Well As Drinking Coffee
(Sunday February 01, 2026 @03:34AM (BeauHD)
from the good-news-and-bad-news dept.)
An anonymous reader quotes a report from Wired:
> About a decade ago, many media outlets -- including WIRED -- zeroed in on a weird trend at the intersection of mental health, drug science, and Silicon Valley biohacking: [1]microdosing , or the practice of taking a small amount of a psychedelic drug seeking not full-blown hallucinatory revels but gentler, more stable effects. Typically using psilocybin mushrooms or LSD, the archetypal microdoser sought less melting walls and open-eye kaleidoscopic visuals than [2]boosts in mood and energy , like a gentle spring breeze blowing through the mind. Anecdotal reports pitched microdosing as a kind of psychedelic Swiss Army knife, providing everything from [3]increased focus to a [4]spiked libido and (perhaps most promisingly) lowered reported [5]levels of depression . It was a miracle for many. Others remained wary. Could 5 percent of a dose of acid really do all that?
>
> A new, wide-ranging study by an Australian biopharma company suggests that microdosing's benefits may indeed be drastically overstated -- at least when it comes to addressing symptoms of clinical depression. A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the [6]Montgomery-Asberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression. The study has not yet been published. But MindBio's CEO Justin Hanka recently released the top-line results on [7]his LinkedIn , eager to show that his company was "in front of the curve in microdosing research."
>
> He called it "the most vigorous placebo controlled trial ever performed in microdosing." It found that patients dosed with a small amount of LSD (ranging from 4 to 20g, or micrograms, well below the threshold of a mind-blowing hallucinogenic dose) showed observable upticks in feelings of well-being, but worse MADRS scores, compared to patients given a placebo in the form of a caffeine pill. (Because patients in psychedelic trials typically expect some kind of mind-altering effect, studies are often blinded using so-called "active placebos," like caffeine or methylphenidate, which have their own observable psychoactive properties.) This means, essentially, that a medium-strength cup of coffee [8]may prove more beneficial in treating major depressive disorder than a tiny dose of acid . Good news for habitual caffeine users, perhaps, but less so for researchers (and biopharma startups) counting on the efficacy of psychedelic microdosing.
"It's probably a nail in the coffin of using microdosing to treat clinical depression," Hanka says. "It probably improves the way depressed people feel -- just not enough to be clinically significant or statistically meaningful."
[1] https://news.slashdot.org/story/15/11/27/1343243/lsd-microdosing-gaining-popularity-for-silicon-valley-professionals
[2] https://science.slashdot.org/story/21/11/19/185230/adults-who-microdose-psychedelics-report-health-related-motivations-and-lower-levels-of-anxiety-and-depression-paper-finds
[3] https://www.businessinsider.com/man-giving-how-to-microdose-lsd-psychedelic-drugs-online-tutorial-2017-10
[4] https://www.medicalnewstoday.com/articles/psychedelics-psilocybin-lsd-help-improve-sexual-function
[5] https://www.nature.com/articles/s41598-021-01811-4
[6] https://www.mdcalc.com/calc/4058/montgomery-asberg-depression-rating-scale-madrs#pearls-pitfalls
[7] https://www.linkedin.com/feed/update/urn:li:activity:7395932768636997632/
[8] https://www.wired.com/story/microdosing-for-depression-appears-to-work-about-as-well-as-drinking-coffee/
> About a decade ago, many media outlets -- including WIRED -- zeroed in on a weird trend at the intersection of mental health, drug science, and Silicon Valley biohacking: [1]microdosing , or the practice of taking a small amount of a psychedelic drug seeking not full-blown hallucinatory revels but gentler, more stable effects. Typically using psilocybin mushrooms or LSD, the archetypal microdoser sought less melting walls and open-eye kaleidoscopic visuals than [2]boosts in mood and energy , like a gentle spring breeze blowing through the mind. Anecdotal reports pitched microdosing as a kind of psychedelic Swiss Army knife, providing everything from [3]increased focus to a [4]spiked libido and (perhaps most promisingly) lowered reported [5]levels of depression . It was a miracle for many. Others remained wary. Could 5 percent of a dose of acid really do all that?
>
> A new, wide-ranging study by an Australian biopharma company suggests that microdosing's benefits may indeed be drastically overstated -- at least when it comes to addressing symptoms of clinical depression. A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the [6]Montgomery-Asberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression. The study has not yet been published. But MindBio's CEO Justin Hanka recently released the top-line results on [7]his LinkedIn , eager to show that his company was "in front of the curve in microdosing research."
>
> He called it "the most vigorous placebo controlled trial ever performed in microdosing." It found that patients dosed with a small amount of LSD (ranging from 4 to 20g, or micrograms, well below the threshold of a mind-blowing hallucinogenic dose) showed observable upticks in feelings of well-being, but worse MADRS scores, compared to patients given a placebo in the form of a caffeine pill. (Because patients in psychedelic trials typically expect some kind of mind-altering effect, studies are often blinded using so-called "active placebos," like caffeine or methylphenidate, which have their own observable psychoactive properties.) This means, essentially, that a medium-strength cup of coffee [8]may prove more beneficial in treating major depressive disorder than a tiny dose of acid . Good news for habitual caffeine users, perhaps, but less so for researchers (and biopharma startups) counting on the efficacy of psychedelic microdosing.
"It's probably a nail in the coffin of using microdosing to treat clinical depression," Hanka says. "It probably improves the way depressed people feel -- just not enough to be clinically significant or statistically meaningful."
[1] https://news.slashdot.org/story/15/11/27/1343243/lsd-microdosing-gaining-popularity-for-silicon-valley-professionals
[2] https://science.slashdot.org/story/21/11/19/185230/adults-who-microdose-psychedelics-report-health-related-motivations-and-lower-levels-of-anxiety-and-depression-paper-finds
[3] https://www.businessinsider.com/man-giving-how-to-microdose-lsd-psychedelic-drugs-online-tutorial-2017-10
[4] https://www.medicalnewstoday.com/articles/psychedelics-psilocybin-lsd-help-improve-sexual-function
[5] https://www.nature.com/articles/s41598-021-01811-4
[6] https://www.mdcalc.com/calc/4058/montgomery-asberg-depression-rating-scale-madrs#pearls-pitfalls
[7] https://www.linkedin.com/feed/update/urn:li:activity:7395932768636997632/
[8] https://www.wired.com/story/microdosing-for-depression-appears-to-work-about-as-well-as-drinking-coffee/