Old Hearts Become Biologically Younger When Transplanted Into Younger People (sciencealert.com)
- Reference: 0186034998
- News link: https://science.slashdot.org/story/26/10/06/0419213/old-hearts-become-biologically-younger-when-transplanted-into-younger-people
- Source link: https://www.sciencealert.com/old-hearts-become-biologically-younger-when-transplanted-into-younger-people
> It might be reasonable to think that there's an indelible link between the heart and the body it resides in -- the processes that affect one inevitably affect the other. But a new preprint, [2]uploaded to bioRxiv and yet to be peer-reviewed, suggests that this may only be true up to a point. Take the heart out of the body and put it in a new one, and something incredible happens. The transplanted heart begins to take on the biological age of its new owner. Older hearts transplanted into younger recipients [3]appear to become biologically younger , while younger hearts placed in older bodies show signs of accelerated aging.
[1] https://slashdot.org/~alternative_right
[2] https://doi.org/10.64898/2026.09.15.751836
[3] https://www.sciencealert.com/old-hearts-become-biologically-younger-when-transplanted-into-younger-people
New Business/Health Plan (Score:2)
1. Swap hearts with a fit young person.
2. After I wear theirs out, we swap back and I get my old, now upgraded, heart back.
3. Profit.
Re: (Score:2)
1. Get off my lawn!
2. (swap hearts)
3. Join me on my lawn, my precious!
GHK-Cu (Score:4, Informative)
A similar thing was found in the 1970s with liver cells, a chemist named Loren Pickart first isolated GHK – a string of three amino acids Glycyl-L-histidyl-L-lysine, after noticing that bathing liver cells in the lab with plasma from younger adults helped revive them.
GHK-Cu has potential for regenerative medicine in many areas, however as it is not patentable it has not seen any proper human trials. It has been used in some expensive skin care products where it has been shown to be effective but that is all. It would be nice to see some proper clinical trials,
Aaand as usual.. (Score:2)
Upon reading the paper I quickly realized, predictably, that it's all baloney. By new heart they mean methylation patterns imprinted in the DNA. Is methylation anything to give a shit about when it comes to the heart? Most likely no. At best you could fool someone like Peter Thiel I suppose. What makes your heart give out is muscle wasting and narrowed or cholesterol'd up blood vessels .. calcification at the valves, fibrous scar tissue. The methylation pattern in the cells don't do anything much, fucked up
Re: (Score:3)
Ironically, restoring the old methylation pattern may increase, not decrease, the risk of cancer. Here's why. When you get older, the risk of a cell's DNA accumulating damage increases. Sometimes, this damage can provide the mutations to make the cell cancerous. In order to prevent that, the cell silences gene expression by methylating sections of the DNA. Reference: [1]https://pmc.ncbi.nlm.nih.gov/a... [nih.gov]
Now when you go and do a fool thing like "restore the reduced DNA methylation patterns typically found in you
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC5657558/
Re: (Score:2)
Talking about fooling, just wait till Trump and Kennedy hear about this!
Re: (Score:2)
> At best you could fool someone like Peter Thiel I suppose.
Isn't that pretty much the standard tech business plan nowadays? Not to build a sustainably profitable company... but to pull something together that offers the best potential for a quick buyout in the shortest amount of time.
Can we extract? (Score:2)
If we can get the"thing that makes them young" into old people they can be young again?! Maybe Vampirism isn't total BS...
Silliness aside, it seems we're getting very close to regeneration and lifespan extension. Anything that will extend old people's lives is generally going to be great for humanity. If I knew in my 20s what I know now sorta thing...
Re: (Score:2)
> If we can get the"thing that makes them young" into old people they can be young again?!
[1]https://www.imdb.com/title/tt0... [imdb.com]
[1] https://www.imdb.com/title/tt0088933/
ship of Theseus (Score:2)
it's the ship of Theseus at play here
Kidneys (Score:2)
Should look at kidney transplants - there are many more to investigate than hearts.
Re: Kidneys (Score:2)
Or take a closer look at blood transfusions.
A biblical verse states the life of an organism is in its blood. It is blood that carries the nutrients, signalling molecules and even free mitochondria that probably signal the transplanted organ to turn younger. The bioelectric environment also matters, but probably not to the same extent as blood does to the transplanted heart.