The Golden Age of Vaccine Development (worksinprogress.co)
- Reference: 0180554760
- News link: https://science.slashdot.org/story/26/01/09/1755211/the-golden-age-of-vaccine-development
- Source link: https://worksinprogress.co/issue/the-golden-age-of-vaccine-development/
In the first half of the 2020s alone, researchers delivered the first effective vaccines against four different diseases: Covid-19, malaria, RSV and chikungunya. No previous decade matched that output. The acceleration rests on infrastructure that took two centuries to assemble. Edward Jenner's 1796 smallpox vaccine was a lucky accident he didn't understand. Louis Pasteur needed ninety years to turn that luck into systematic methods -- attenuation and inactivation -- that could be applied to other diseases. Generations of scientists then built the supporting machinery: Petri dishes for bacterial culture, techniques to keep animal cells alive outside the body, bioreactors for industrial production, sterilization and cold-chain logistics.
Those tools have now compounded. Cryo-electron microscopy reveals viral proteins atom by atom, a capability that directly enabled the RSV vaccine after earlier attempts failed. Genome sequencing costs collapsed from roughly $100 million per human genome in 2001 to under $1,000 by 2014, according to data from the National Human Genome Research Institute. The mRNA platform, refined through work by Katalin Kariko, Drew Weissman, and others, allows vaccines to be redesigned in weeks rather than years. The trajectory suggests more breakthroughs are possible. Whether they arrive depends on continued investment, however.
[1] https://worksinprogress.co/issue/the-golden-age-of-vaccine-development/
Golden age coincides with 5G!? (Score:1, Insightful)
Also: flat earth, fake moon landing, p3d0 island, lizard people!
hrm, maybe you're on to something here (Score:1, Troll)
Can we describe the vaccines themselves as golden? As in .. made of gold? That seems to be one of the few things that gets Trump's interest.
For the US, it's a combo golden age and dark age (Score:5, Insightful)
At exactly the same time. Vaccines themselves are leaping forward and will protect from all sorts of stuff. Meanwhile, US public health policy has retracted by about a century, and misinformation spreads like hellfire. Thankfully, the doctors won't participate in that bulls^&t. If you listen to the doctors, you'll probably be fine. If you listen to the internet of the government health advice, you're boned.
In the end, this might sort itself out. The smart people will vaccinate, and the dumb people will die more often. If the effect is severe enough, the differential death rates might just offset the idiocracy effect.
During COVID, I knew a family that was 100% covid denier. To them, covid was a liberal conspiracy, the vaccines were mind control, masking was fraudulent and ineffective and social distancing was a form of government control. They went about their lives like everything was normal, right at the start of the pandemic when the virus had just made the species jump and was at peak deadliness. The dad caught covid. Then his son caught covid. Then the dad died. Then the son died. The son was reproductive age. It was really, really sad, but it was like watching a nature special about evolution, complete with Attenborough's narration. Straight-up evolution in action. They made some stupid choices, of their own free will, and now that genetic line is *gone*.
Re: For the US, it's a combo golden age and dark a (Score:2)
Please tell me, out of the billion or so kids that had it... How many died? Also please cite the study indicating the vaccines caused more aggressive cancer while excluding the hundreds of other toxins people are exposed to every day.
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I will, if you first cite to me legitimate, peer-reviewed studies showing any of these vaccines are safe and effective.
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Are you serious? That's completely opposite of my experience. Are you located in the US? Smart people are much more likely to be college educated, and vaccination rates among college educated are WAY higher.
I gotta assume that you're trolling.
Re: For the US, it's a combo golden age and dark a (Score:4, Insightful)
None of them have any evidence ever. They just talk and expect people to believe them.
Re: (Score:1)
> Smart people are much more likely to be college educated, and vaccination rates among college educated are WAY higher.
Take a look at the Covid vaccination stats. Smart people and dumb people were the least likely to get vaccinated.
The typical "college-educated smart people" are midwits, who believe everything they're told. Which rather demonstrates my point.
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> They made some stupid choices, of their own free will, and now that genetic line is *gone*.
Thanks, I needed some cheering up today.
I predict that... (Score:2)
...Trump and the MAGAts will declare vaccine researchers enemies of the state and have them imprisoned or executed
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> ...Trump and the MAGAts will declare vaccine researchers enemies of the state and have them imprisoned or executed
Of course, that's just hyperbole. What's not hyperbole is using federal funding of research and programs to cancel ideas and people that they don't like. Tens of billions of dollars and at least tens of thousands of researchers and medical personnel have lost their funding and some of them their jobs. There's no need to imprison or execute when simply killing their programs does the same thing.
It's weird (Score:2)
Because ten years ago they couldn't even get mRNA treatments for cancer approved on safety grounds, and many companies in the field abandoned it because they believed mRNA would always be too toxic to use on a large scale.
[1]https://archive.is/KMWgt [archive.is]
[1] https://archive.is/KMWgt
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hey here's a protip, you should read the articles you post because none of that is in there, the story is "they're working to figure mRNA vaccines out" and guess what, they did, and not only did they but a whole ass other company did too.
time moves in one direction
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Here's a quote from the article for you:
"Delivery — actually getting RNA into cells — has long bedeviled the whole field. On their own, RNA molecules have a hard time reaching their targets. They work better if they’re wrapped up in a delivery mechanism, such as nanoparticles made of lipids. But those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years.
Novartis abandoned the related realm of RNA interference over concern
Re: It's weird (Score:5, Insightful)
Considering only a handful of people died out of 3 billion doses or more, either you knew extremely unlucky people or you are full of shit. Either way, we know not many people died from it from the experience of the world and all you have are anecdotes. You don't even know if they died because of the vaccine. It is statistically way more likely to die of the virus itself. They are still finding organ damage in people who had it months ago.
Re: It's weird (Score:4, Insightful)
There is no such thing as "turbo cancer". If anyone who got the shot then got cancer, they had cancer prior to the shot. There is no other way it could happen.
Now back to your inane ramblings.
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"There is no such thing as "turbo cancer". If anyone who got the shot then got cancer, they had cancer prior to the shot. There is no other way it could happen."
That kind of argument is why no-one takes "The Science" seriously any more.
We know the friend who survived didn't have cancer before the shot because they'd had cancer a few years before and were being regularly monitored in case it came back. Then they got injected, and oops, rapidly-growing cancer much worse than they had before. The other was per
Re: It's weird (Score:1)
so you're ignorant of cancer recurrence rates and ignorantly blame a vaccine.
meanwhile no vaccinated people I know have cancer, but two unvaccinated ones did because of other self-destructive behavior that we can add to their list that included vaccine avoidance.
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The people who claim they don't trust the science are the same ones who will tell you they did their own research.
Youtube partly to blame (Score:4, Interesting)
I know an anti-vaxer who gets all his info from Youtube. The algorithm notices 'oh you like anti-vaxer videos, here are more like that!' And down the rabbit hole they go.
Covid 19 (Score:1)
Queensland Australia, had a unique experiment. Our borders were locked and we had no C19, until the govt thought enough of us were vaxxed and opened the borders. The govt published daily deaths, was COVID present at time of death(not cause just active) , how many C19 vaccinations they had and their decile age range. I recorded the data for about 8 weeks as I was interested as an engineer if I could see efficacy.
The data clearly showed if you were under 50 vaccination status made no difference to mortality.
Re: Covid 19 (Score:3)
What about the elderly people those 50 year olds were around? Vaccination isn't just to help you, it's to help the people around you. Yours is an extremely self-centered view.
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The only way the vaccination helps the elderly is if the vaccinated do not catch the disease and therefore do not expose them to it. Obviously, that was not the case with the COVID vaccination because it did not prevent catching the disease. I personally am fully vaccinated and still caught it (of course). I personally assume my immunity was helped more by catching it and recovering than from the vaccinations I received prior to having COVID. The best way to avoid giving the disease to the most at risk is t
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Besides the elderly getting the vaccination themselves I should say. Then they can cross their fingers that it actually makes the disease that they will likely catch anyway be less severe.
Science is moving ahead very fast. (Score:2)
Science is improving our lives, in many areas, very rapidly.
It often happens that mistakes are made, and are later corrected.
For the whiners (Score:3)
If you're adamant that, like the anti-vaxxer Robert F. Kennedy, Jr, vaccines are not safe, let's here your excuses for why disease cases [1]plummeted when vaccines were administered [imgur.com].
Side note, if you look below the first heat map, you'll notice the CDC no longer published measels cases after 2002. Think real hard why that might be and why we now have over 2,100 cases in five months.
[1] https://i.imgur.com/PBSsNQl.png
The first effective vaccine against Covid-19 (Score:1)
In the first half of the 2020s alone, researchers delivered the first effective vaccines against four different diseases: Covid-19
Then why the need for repeated booster Covid-19 shots? Because repeated Covid-19 vaccination of an already infected population accelerated the mutations.
Re: The first effective vaccine against Covid-19 (Score:1)
viruses mutate by themselves and later variants were milder. No need for a vaccine now, unlike with the initial deadly variants
300 years of scientific progress (Score:5, Insightful)
Thown away in one year of Trump and RFK.
Re: 300 years of scientific progress (Score:1)
nonsense, private companies made the montioned vaccines and you can get them