New Alzheimer's Treatment Clears Plaques From Brains of Mice Within Hours
(Thursday October 16, 2025 @03:00AM (BeauHD)
from the cognitive-cleanup dept.)
- Reference: 0179804210
- News link: https://science.slashdot.org/story/25/10/16/0245204/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours
- Source link:
Scientists from Spain and China have [1]successfully repaired the blood-brain barrier in Alzheimer's-model mice , enabling the brain to naturally clear amyloid-beta plaques and reverse cognitive decline. "After just three drug injections, mice with certain genes that mimic Alzheimer's showed a reversal of several key pathological features," adds ScienceAlert. From the report:
> Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease. The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months.
>
> These preclinical results don't guarantee success in humans, but they're an encouraging start, which the authors [2]say "heralds a new era" in drug research. "The therapeutic implications are profound," [3]claim the international team of researchers, co-led by scientists at the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU).
The findings have been [4]published in Signal Transduction and Targeted Therapy .
[1] https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours
[2] https://doi.org/10.1038/s41392-025-02426-1
[3] https://doi.org/10.1038/s41392-025-02426-1
[4] https://doi.org/10.1038/s41392-025-02426-1
> Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease. The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months.
>
> These preclinical results don't guarantee success in humans, but they're an encouraging start, which the authors [2]say "heralds a new era" in drug research. "The therapeutic implications are profound," [3]claim the international team of researchers, co-led by scientists at the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU).
The findings have been [4]published in Signal Transduction and Targeted Therapy .
[1] https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours
[2] https://doi.org/10.1038/s41392-025-02426-1
[3] https://doi.org/10.1038/s41392-025-02426-1
[4] https://doi.org/10.1038/s41392-025-02426-1
Please continue. (Score:1)
by rongten ( 756490 )
There is nothing more devastating for a family to assist to a loved one descent in Alzheimer hell.
The more you love the victim, the more the sickness is cruel to you.
if i could identify as a mouse (Score:1)
by NewID_of_Ami.One ( 9578152 )
It does seem quite promising from the paper with the multitude of different tests / processes they have used to check that it's working
Now if i could identify as a mouse i might even be able to get in the program and avoid any future Alzheimer stuff. What do you mean I Can
heroic dose (Score:2)
by zaax ( 637433 )
As people with Alzheimer's will died in the near future why don't they try it on a few Alzheimer's patients? If it doesn'tt work no harm done
In mice (Score:2)
This week's "in mice" medical result.
Re: (Score:2)
Hell no! No Alzheimer's hacking in my mouse! No sir! You can pry my Logitech mouse from my cold, dead hands!