COVID-19 Vaccine's mRNA Technology Adapted for First Antibiotic-Resistant Bacteria Vaccine (medicalxpress.com)
- Reference: 0178372142
- News link: https://science.slashdot.org/story/25/07/14/0420225/covid-19-vaccines-mrna-technology-adapted-for-first-antibiotic-resistant-bacteria-vaccine
- Source link: https://medicalxpress.com/news/2025-07-covid-vaccine-technology-mrna-defense.html
Medical Express [1]publishes their announcement :
> The vaccine developed by the team from the Institute for Biological Research and Tel Aviv University is an mRNA-based vaccine delivered via lipid nanoparticles, similar to the COVID-19 vaccine. However, mRNA vaccines are typically effective against viruses like COVID-19 — not against bacteria like the plague... In 2023, the researchers developed a unique method for producing the bacterial protein within a human cell in a way that prompts the immune system to recognize it as a genuine bacterial protein and thus learn to defend against it.
>
> The researchers from Tel Aviv University and the Institute for Biological Research proved, for the first time, that it is possible to develop an effective mRNA vaccine against bacteria. They chose Yersinia pestis , the bacterium that causes bubonic plague — a disease responsible for deadly pandemics throughout human history. In animal models, the researchers demonstrated that it is possible to effectively vaccinate against the disease with a single dose.
The team of researchers was led by Professor Dan Peer at Tel Aviv University, a global pioneer in mRNA drug development, who says the success of the current study now "paves the way for a whole world of mRNA-based vaccines against other deadly bacteria."
[1] https://medicalxpress.com/news/2025-07-covid-vaccine-technology-mrna-defense.html
Re: (Score:1)
And the data that makes this a "fact" and not your opinion is.... where?
Re:effective? (Score:5, Informative)
la Presidenta did not handle COVID as well or better than Biden. If you recall, he was promoting Hydroxychloroquine for COVID. That's as bad a promoting Vitamin A for measles as the JFK, Jr. was doing. Then la Presidenta had the bright idea of shining fluorescent light inside people, "knocks it right out of there". Then it would magically go away by summer, insinuated it didn't like the heat.
Meanwhile, the cases built up. Finally we got the vaccine. However, his bush-league team left the incoming administration no plan for rollout because that would have required competent planning. Later, he waffled on the vaccine aiming to pull in the anti-vax crowd.
Biden's team put together a rollout plan and then followed through.
Re:effective? (Score:5, Informative)
Trump did create the vaccine under Operation Warp Speed. But then MAGA brain rot led him to getting booed when he told people to take his wonderful vaccine. [1]https://www.nbcnews.com/politi... [nbcnews.com]
[1] https://www.nbcnews.com/politics/donald-trump/trump-booed-alabama-rally-after-telling-supporters-get-vaccinated-n1277404
Re: (Score:3)
> Trump did create the vaccine under Operation Warp Speed
Nope. He did not "create the vaccine." He agreed to let the government throw some money around to various companies who wanted to try to make a vaccine with the agreement that the government would get first dibs on any successfully created vaccine. In fact, as a taxpayer who probably paid more in taxes than Trump during those years, I likely had a bigger role in "creating the vaccine" than Trump.
Re: effective? (Score:3)
The COVID mRNA vaccines were the culmination of decades of research into genetic vaccines that could be in essence engineered to target a selected antigen without the years of trial and error that are required by the methods we have been using since the 1950s. Within days of the virus genome being published, they had a vaccine design, the months it took to get to the public were taken up with studies of the safety and effectiveness of the heretofore untested technology, ramping up production, and preparing
Re:effective? (Score:5, Informative)
Thanks to propaganda promulgated by idiots like you, we ended up with a real-world A / B trial of the Covid-19 vaccines. A lot more Republicans ended up dead because they didn't get the shot:
[1]https://www.pewresearch.org/po... [pewresearch.org]
Yes, it was effective.
And here's an actual study about deaths from the vaccine itself (tl;dr - your claims are bullshit):
[2]https://pmc.ncbi.nlm.nih.gov/a... [nih.gov]
[1] https://www.pewresearch.org/politics/2022/03/03/the-changing-political-geography-of-covid-19-over-the-last-two-years/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8875435/
Re:effective? (Score:5, Insightful)
I am just starting to assume that the anti-vaxxers are posting from Russian Troll farms as a cheap way to kill stupid Americans.
Re:effective? (Score:5, Insightful)
Don't Russian troll farms want the stupid ones to survive? It's the intelligent Americans that they would be opposed to.
I think it's just an effort to cause general division and conflict, as well as worsening America's health overall.
Re: (Score:3)
Good point! It worked amazingly well!
Re:effective? (Score:5, Insightful)
It's worse than that. People should have learned from the pandemic. When we collectively get together to push development of these things forward, the results are hugely beneficial. Governments acting on our behalf to get mRNA vaccines funded and released in record time is going to have long term positive effects for all sorts of conditions.
The same thing happened during WW2. Massive advances in technology. In the UK after the war, the new socialist government ran on a platform of continuing those big national collaborative projects, and the benefits were huge. Lots of infrastructure, affordable housing, socialized healthcare, a state pension... The US did some similar things with the GI Act, and also back in the 1930s with the New Deal, and again with Apollo.
What makes it worse than just rejection of science is rejection of the kind of collaboration and national projects that reap huge rewards.
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Those articles are from early 2022. They are not trustworthy.
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VAERS != robust data or evidence
Look, everyone, another clueless fartkwit pushing FuD as if it were fact!
Chuckledinks. Chuckledinks all the way down.
Re: (Score:2)
And Covid killed over 1 million Americans and many more world-wide.
"they have not to date been effectively controlled by licensed or experimental vaccines".
I suppose you can call them experimental, but they've been developed starting with research since the beginning of the Bush, Jr. admin. The reason they were able to field them so quickly, about a year from when cases appeared in the U.S., was that the drug companies had been preparing them. That is, they had already extensively tested them. And you can c
Re: effective? (Score:3)
The excess deaths metric doesn't care about attribution. We can see how that changed during those years.
Re:effective? (Score:5, Informative)
According to FDA and CDC data, the covid 19 vaccine killed over 4800 people
No, it didn't. Not even close. As of 2023, there were [1]9 confirmed deaths [apnews.com] related to the vaccine itself, and those were only related to the Johnson & Johnson vaccine.
That fake number you pulled out of your ass [2]was debunked years ago [nih.gov].
> After careful review of the reports, there is no enough evidence that the COVID-19 vaccine contributed to those fatalities [16]. Clinical information such as death certificates, autopsy, and medical records establish no causal link to the COVID-19 vaccines according to the CDC. The death of a person following vaccination does not necessarily mean, the vaccine caused health problems and could be coincidental. Research done by the Paul Ehrlich Institute (the body in charge of vaccines in Germany) stated that patients died of their underlying diseases in a coincidental time with vaccination. This came after 10 COVID-19 vaccination deaths were recorded in the country [17]. Early studies conducted by the Norwegian Medicine Agency on reports of 33 deaths in a nursing home following vaccination of residentsâ(TM) revealed death occurred close to these terminally ill patients at the time of vaccination [17]. It does not imply a causal relation to the vaccine [17].
and had 380k adverse reactions,
Once again, stating things which are not true. The VAERS database lists any reaction of any kind after taking medicine, REGARDLESS if there is any casual link. If I take Advil then get a rash three days later, did Advil cause it or it is poison ivy?
Pointing to a conspiracy site does not help your cause.
[1] https://apnews.com/article/fact-check-cdc-covid-vaccine-deaths-910677348223
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8511593/
Real fact check: (Score:4, Informative)
> Claim:
> According to FDA and CDC data, the covid 19 vaccine killed over 4800 people and had 380k adverse reactions, in 6 months.
Fact check: There are hundreds of reports of 4800 people having died within two days of getting a COVID vaccine but that does not necessarily mean the vaccine was the cause. Similarly, 380k adverse reactions were reported but not definitely the caused by the vaccine. Finally, given the breadth of deployment, the mRNA vaccines were the safest vaccines ever made. They aren't perfect because humans are not all identical but they were damn close.
I would also point out there there were about 600 people who died from overdosing on hydroxychloroquine which is not effective at treating or preventing COVID-19.
Re:Real fact check: (Score:5, Interesting)
Correction: like the name of the database says, there are 380k reports of adverse events after people got vaccinated. Study is required to determine whether those were reactions or coincidences (or indirect consequences).
After I got the first two COVID-19 shots, I got a survey that asked whether I had seen a doctor for any illness since then. I truthfully answered: I had a tick bite that ended up with a rash around it, and I went to a doctor to exclude Lyme disease as a cause. When I later doing it about VAERS, I searched and found an entry that signed like mine. I don't know for sure it was about me, but I do know that tick bite and infection had nothing to do with a vaccine.
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To say nothing of the the 2000+ cases of people stripping out their large intestines with ivermectin who now have to have colostomy bags.
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> Finally, given the breadth of deployment, the mRNA vaccines were the safest vaccines ever made. They aren't perfect because humans are not all identical but they were damn close.
Ever wonder how many people who harmed or killed themselves with alternative treatments could have been saved if only the mRNA vaccine manufacturers didn’t try and hide every shred of trial evidence proving how safe their vaccine was?
You’re right. They aren’t perfect. And THAT was the fucking honesty every victim citizen was asking for. They got marketing instead.
Re: (Score:2)
> THAT was the fucking honesty every victim citizen was asking for.
Bullshit. They wanted something something simple, declarative and especially something aligned with their personal delusions, mostly informed by FuD they absorbed from social media.
Let's quit pretending humans are perfectly rational.
Re: (Score:3)
So it wa highly successfull with minimal side effects. 270,227,181 people have received a dose and only 4800 died. 1,193,165 confirmed covid deaths in the US. The odds are better to just take the vaccine. So it was highly successful.
So what are the advantages of mRNA? (Score:2)
Why wouldn't this work with a subunit + adjuvant vaccine? Or a viral vector instead of a non biological vector?
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As a layman, the basic difference is that traditional vaccines are created from viruses, buy rendering them harmless, while mRNA vaccines are kind of "programmed", or "engineered" from scratch. I think this is an exciting progression, and may be as important as the discovery and refining of Penicillin itself that has saved hundreds of millions of lives and limbs.
Re: (Score:2)
The ones I mentioned are all engineered. Subunit puts the proteins in some porous adjuvant, mRNA uses the lipid nanoparticle as an artificial vector to get mRNA into cells and have it reproduce the protein, viral vector does the same though the viral vector can be more selective in what cells to infect. Both mRNA and viral vector can use amplification inside the cell.
The viral vector can be attenuated by pre-existing resistance, but the lipid nanoparticle can have increasing immunogenic reactions with each
Re:So what are the advantages of mRNA? (Score:5, Insightful)
> Lipid nanoparticles to me seem the method with the highest odds of unintended consequences
I mean we can think that but where is the evidence, after billions of shots into billions of people for 5 years now? So we have combined how many billions of doses for a 5 year timespan, at a certain point we can stop surmising and start making true statements.
Seriously, I have been hearing the "what if" crowd since Jan 2021 and they have been wrong at every time. It was 1 year, then 2 years, then 3 years, then 5 years. Will the adverse effects show up in 10 years? 20? Can we approve new medicine ever?
I'm sorry but the vaccine skeptic crowd is not interested in medicine, they are interested in political gains and antivax has just become another part of that.
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The existing side effects are unintended consequences and help drive vaccine hesitancy. Take something like whole cell pertussis, the side effects were so bad it caused a huge dip in vaccine acceptance.
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Nah, I still blame the skeptic crowd, even with pertussis the effects were acture and any long term issues were determined to be unrelated to the vaccines but that didn't stop that crowd from perpetuating this idea that "vaccines have zero side effects any any side effects at all is unsafe".
Also the pertussis incident makes the case for more mRNA since that vaccine was a whole virus and mRNA is exactly not that, those types of reactions are eliminated with mRNA.
So why is the skeptic crowd up in arms about v
Re: (Score:2)
Blaming humans for being humans won't change the outcome.
Even nurses got vaccine hesitancy from the severity of the side effects from mRNA vaccines.
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No I do blame humans for their bad logic, bad conclusions and falling into bad faith political conspiracy theories. I blame them, the media who pushes them and people like you who also push it hesitantly and cowardly.
They have no evidence, don't care about science, don't care about medicine. Only what is politically advantaged to their cause which has little to do with science and everything to do with disliking liberals.
I am no longer giving skeptics any benefits of the doubt. They were wrong then and t
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By and large nurses aren't skeptics, they just don't like feeling sick.
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Nurses are not immune to online conspiracy dealers. Do they have evidence or is this about their feelings?
If they are unwilling to research this stuff or have qualms with the science and process that maintain their entire career maybe they should get a new career. You don't have a right to a job as a nurse.
I work in audio visual, if I believed light waves from projectors are a government conspiracy that gives people cancer then maybe I should get a new career because obviously I have no interest in the work
Re: (Score:1)
> Seriously, I have been hearing the "what if" crowd since Jan 2021 and they have been wrong at every time. It was 1 year, then 2 years, then 3 years, then 5 years. Will the adverse effects show up in 10 years? 20? Can we approve new medicine ever?
Karl Lauterbach, Germany's Minister of Health throughout covid, has completely reversed his position and is now admitting tens of thousands of severe adverse events are flooding germany's medical system. The German mainstream media hav openly called him and the government out on lying and claiming perfect safety and efficacy.
The German government initially admitted the rate of severe life-altering side effects (including deaths) was 1 in 10,000 at an absolute minimum. This was confessed after one of their l
Re: (Score:2)
In the case of Covid-19 vaccines, mRNA ones turned out to be clearly superior.
I had one of each, which may have had a slight advantage over a booster of the same, but mRNA had lower rates of complications.
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Evidence is mixed :
[1]https://www.sciencedirect.com/... [sciencedirect.com]
Despite TTS in young women, Jannsen was a huge positive outlier in minor side effects for the major vaccines used in the population wide experiment. Novavax subunit vaccine seems to have been better tolerated than mRNA vaccines too, though it came too late to benefit from the full experiment.
[1] https://www.sciencedirect.com/science/article/pii/S1198743X23006006
Re:Bad idea (Score:5, Insightful)
"Why do scientists focus on medicine that works instead of medicine that doesn't because one those I have to oppose due to politics so can the researchers please take my hurt feelings into account."
Re: (Score:2)
The narrative will change. Anti-vaxers will vanish for the most part because it was always a political narrative as part of the destruction of the rule of law - Which has been accomplished in spades.
Now that they get to control the rules, science that works under those rules is "good" science.
Re: (Score:2)
I don't watch bitchute videos as a general rule, I'm afraid they will turn my brain to mush. May I suggest that you at least add AP to your 'diet' of "news"?
Re: (Score:1)
[1]gish gallop [wikipedia.org]
[1] https://en.wikipedia.org/wiki/Gish_gallop
Why plague? Nobody gets the plague anymore (Score:2)
Why plague? I'd rather have a vaccine against something I actually have a chance of getting. But the answer is at the end of the article:
> "The disease is caused by a bacterium called Yersinia pestis, for which there is no approved vaccine in Western countries. This bacterium is highly contagious and extremely lethal, making it a serious threat. Moreover, this bacterium concerns us as a potential agent of bioterrorism. If one of our enemies tries to use it against us, we want to be prepared with a vaccine."
Grants are probably very available for bio-weapon defense. Or at least normally they would be. I've heard science funding is a bit of a mess.
Re: Why plague? Nobody gets the plague anymore (Score:5, Informative)
[1]https://www.nbcnews.com/news/a... [nbcnews.com]
Just because You don't know about it, doesn't make your statement true.
[1] https://www.nbcnews.com/news/amp/rcna218251
Proof of concept (Score:5, Interesting)
> Why plague?
It's both interesting and distinct which has resulted in a lot of studies of Yersinia pestis. This has yielded a firm understanding of it's mechanisms. When making a proof of concept treatment, you first target a well understood target which makes Yersinia pestis an ideal target. A simple misunderstanding of the target bacteria's function could result in years of wasted efforts or delays.
A similar phenomenon exists for when we want to utilize a mechanism found in biology for our own ends. A good example of this is the use of HIV to design a retroviral vector for a gene therapy. It's been studied so much that we know a great deal of how it works.
> I'd rather have a vaccine against something I actually have a chance of getting.
Yersinia pestis is something you can get if you visit a national park because it's carried by rodents. See also: [1]https://science.slashdot.org/s... [slashdot.org]
[1] https://science.slashdot.org/story/25/07/12/1834224/northern-arizona-resident-dies-from-plague
Re: (Score:2)
Plague has a very effective vaccine aleady. However, because of its very low incidence, it's safer to not provide everyone with the vaccine - only those who are likely to encounter it with an increased risk (exterminators, for example). At this point for the vast majority of people it's an unnecessary shot so it's better to not have it.
If you do get it and are unvaccinated, antibiotics generally are very effective if caught early. Though there have been a couple of incidents where it's been resistant, so it
Re: (Score:2)
> I've heard science funding is a bit of a mess.
In the US, yes. This is Israel, and I guess they have reason to worry about bioterrorism. Goes with the territory when you spend your time kicking hornets nests.
Re: (Score:1)
What hornet's nest did the Jews of Hebron kick in 1929 when entire families were mutilated to death and children as young as 13 raped on their dying parents' entrails?
People have been blaming Jews for the massacres and genocides committed against them for as long as there have been Jews to blame. You're not as original as you think you are.