Psilocybin Treatment Extends Cellular Lifespan, Improves Survival of Aged Mice
- Reference: 0178331176
- News link: https://science.slashdot.org/story/25/07/11/0354259/psilocybin-treatment-extends-cellular-lifespan-improves-survival-of-aged-mice
- Source link:
> A [2]newly published study in Nature Partner Journals' Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, extended the cellular lifespan of human skin and lung cells by more than 50%. In parallel, researchers also conducted the first long-term in vivo study evaluating the systemic effects of psilocybin in aged mice of 19 months, or the equivalent of 60-65 human years. Results indicated that the mice that received an initial low dose of psilocybin of 5 mg, followed by a monthly high dose of 15 mg for 10 months, had a 30% increase in survival compared to mice that did not receive any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth.
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> While traditionally researched for its mental health benefits, this study suggests that psilocybin impacts multiple hallmarks of aging by reducing oxidative stress, improving DNA repair responses, and preserving telomere length. Telomeres are the structured ends of a chromosome, protecting it from damage that could lead to the formation of age-related diseases, such as cancer, neurodegeneration, or cardiovascular disease. These foundational processes influence human aging and the onset of these chronic diseases. The study concludes that psilocybin may have the potential to revolutionize anti-aging therapies and could be an impactful intervention in an aging population.
[1] https://neurosciencenews.com/psilocybin-longevity-aging-29425/
[2] https://www.nature.com/articles/s41514-025-00244-x
Hallucinating (Score:1)
The scientist who were conducting the study were hallucinating the results.
Re:Hallucinating (Score:4, Interesting)
No, but the mice were tripping absolute fucking balls once a month.
According to psychonautwiki, 15mg of psilocybin is a 'common' dose for a human : [1]https://psychonautwiki.org/wik... [psychonautwiki.org]
Mice are going to see the color of time in a proton on a dose like that.
From TFA: "Within 30min post-treatment, mice exhibited increased head-twitch response (data not shown), which is a well-established behavioral indicator of hallucinogenic impacts of psilocybin in mice."
[1] https://psychonautwiki.org/wiki/Psilocybin
Re: (Score:1)
The mouse equivalent of a "heroic dose." Bless their little hearts.
Re: (Score:3)
For the common species Psilocybe cubensis, a gram of dried mushrooms can contain 10–12 mg of psilocybin
I am pretty sure that most humans are taking 3-7 grams of mushrooms when they dose
Just sayin
Re: (Score:2)
The mice experienced longer lifespans as long as the researchers kept them from trying to flap their wings and fly.
Re: (Score:2)
I'm volunteering you for the ole suicide booth.
Re: (Score:2)
It's a fair question though. Living longer, falling birth rate. No way to fix either without it being kinda brutal.
We will just have to figure out how to deal with it, and it isn't going to be pleasant.
Re: (Score:2)
Imagine old people collectives (farms), where we (I'm 67) are sent to live and work out our last years. All dogs and cats roam free.
You can live there forever but 75% of your social security is your cost, and you can't leave.
(golly another NetFlix elevator pitch)
Re: (Score:1)
They have those in Israel. They're called kibbutzim. I feel like you can probably automate all that food production though for less than the latest billionaire tax break.
Re:Another way to bankrupt Social Security (Score:4, Insightful)
longer lifespans for the wealthy, longer working lives for the rest
Re: (Score:2)
Look at the rest of his post history. He's not asking questions, he's pulling propaganda out his ass.
Re: (Score:2)
just waiting around for silvergun to tell us how a bunch of doctors with clipboards and data prove that we should all be munching on mushrooms because it's all safe and everything
anyone who's ever done them and gone into the crazy zone will tell you... it's not all fun and games... that can be terrifying to anyone who hasn't been there, which I'm feeling is most people expressing firm opinions on this matter. Lives can be ruined. This is like serving 12 oz vodka martinis to 60 pound 10 year olds. Chances of
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...and the environmental impact... and the resource and enegy consumption...
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Not sure where you are coming from, but for me a longer life means a longer working life, mainly because I ENJOY my work
Schedule 0 listing incomming (Score:3, Insightful)
Oh look. A natural product that has clear benefits and is available for free! BAN IT!!
If big pharma isn't in the loop, nobody is cashing in and we can't have that!
THINK OF THE SHAREHOLDERS!
Re: (Score:3)
Uhm, this is not available for free. Anyone that has attempted to grow any plant knows it is not easy, takes effort, knowledge, money to make them grow. Farmers are hard working people that often lose money in a bad year, not lazy people sitting around doing nothing but picking the plant.
Also, most farms now have shareholders. And quite a few of them use pesticides etc. without regard for their customers health. Generally farmers are more ethical than pharmaceuticals, but not always. (Mainly because fa
Re: (Score:2)
The COST of a dose of mushroom is TINY compared to the RISK of criminal prosecution and the associated costs that go with arrest and prosecution
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Psilocybin is not available free? Maybe not to you, but I know what they look like and where they grow.
Stress reduction? (Score:2)
Could this be due to stress and cortisol reduction caused by the drugs effects? Not unlikely, right?
It causes hallucinations, right? (Score:4, Insightful)
Forgive me as I'm not very familiar with psychoactive substances. Psilocybin causes hallucinations, right? That seems like kind of a big side effect for someone who just wants to take a pill to stay healthy longer.
Re: (Score:1)
Side effect? You make it sound like a bad thing.
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Summary has it wrong. Psilocin is what causes effects in human beings, Psilocybin is a pro-drug...
Re:It causes hallucinations, right? (Score:4, Funny)
If you hallucinate enough you can become as smart as AI.
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That sounds like something an AI would say.
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It would be refreshing if someone named an LLM "know-nothing cunt."
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Depends on the dose. This is not to be joked about, inexperienced people tripping balls on mushrooms/psilocybin guided by people who only read about it is a recipe for disaster.
It can be a wonderful experience! But please approach with caution!! Start with smaller doses to get a feel before diving in.
Good loving friends and a campfire outdoors is the way to go... not effing doctors and clinics.
Seriously the people promoting this are in it for the money, I think that tells you what you need to know.
Re: (Score:2)
Way to contradict yourself.
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For the vast majority of people their first experience with shrooms is jumping in unprepared. And in almost all cases that's fine.
You don't need a shaman to dip your toes in the river. Or even to cannonball into the deep end. The structure is great to improve the quality and intent of your trip, but the drug isn't lying in wait to ambush the unprepared. It's pretty well behaved.
For every "bad trip" there are vast numbers of perfectly mundane ones.
Now a caveat. The easier you find it being in your own skin,
"Treatment" wink wink (Score:1)
Looking forward to some "treatment" this weekend. Gonna do some telomere maintenance and DNA repair out on the ranch under the stars. I'll take my telescope to help distract me from any "side effects."
WRONG USE PERCENTAGES HERE (Score:3)
Mice live about 18 months. A 10% increase is about 2 months. Some idiot sees the 10% increase and thinks 10% of 80 years = 8 years more human life. Nope. Longer lived creatures tend to benefit far less from these things. If something adds 2 months to a mouses life span, it will likely add about 2 months to a human's life span, not 8 years.
Re: WRONG USE PERCENTAGES HERE (Score:2)
That's at least 60 more times to wack off. At least that's how I would spend the extra two months.
Be happy, is the key. (Score:2)
Happy and content individuals live longer. Big reveal.
Unfortunately, the ability to be constantly happy is largely a function of our genetic disposition. It's not a choice, it's an accident. Unhappiness drives the ever oingoing change, which is why I think so many people are unhappy.
Come for the high (Score:2)
And stay, and stay, and stay...
So long-term... (Score:2)
What will a society of 150-year-old hippie mystics lookalike?
Excellent. (Score:2)
Not only a longer life, but one filled with an awareness of nuance and a love of nature at night. Count me in.
Re: (Score:2)
Technically a European mushroom. In this case, the Australian cook is to blame.
updated version:
> If our spiders and snakes don't kill you, our [delicious recipes] will.