Japan's RIKEN scientific research institute and Fujitsu are working with America's Argonne National Laboratory (ANL) and Nvidia to build and operate next-gen compute infrastructure for AI and high-performance computing (HPC), in line with President Trump's Genesis Mission.

RIKEN says the four organizations have agreed a memorandum of understanding (MoU) to develop system software and applications for science and engineering purposes, and promote the use of AI for scientific research.

Areas where the group is expected to cooperate include future computing architectures, where they'll jointly define and prototype next-gen tech for typical HPC workloads such as modeling and simulation, but also the integration of AI into these workflows.

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RIKEN claims the participants hope to develop a shared software ecosystem, in the form of an open and interoperable software stack to support AI-enabled scientific discoveries.

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In addition, the organizations will team up to develop autonomous laboratory workflows to advance the integration of AI and physical science, as well as the convergence of quantum computing and supercomputing.

"RIKEN will lead global efforts in advancing sophisticated use of AI technologies for scientific research through this four-party agreement within the framework of Japan-US cooperation aligned with the US Department of Energy's (DOE) Genesis Mission," said the research institute's President Makoto Gonokami.

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[5]Unveiled last year , Genesis was pitched by the Trump administration as a national effort to develop and use AI for scientific discoveries.

So it seems Tokyo is not too worried about aligning itself with Washington on science and technology, while governments and businesses in Europe are [6]growing increasingly concerned about their own reliance on US tech giants for cloud services and other areas of compute.

"This collaboration represents a pivotal step forward in harnessing the transformative potential of AI and high-performance computing to address pressing scientific challenges in energy, national security, and fundamental research," said Argonne's Laboratory Director Paul Kearns.

[7]DOE recruits cloud, chip, and AI giants for Trump's Genesis Mission

[8]Trump's AI 'Genesis Mission' emerges from Land of Confusion

[9]Trump wants to turn it on again with 'Genesis Mission' for AI in science

[10]Japan's Fugaku supercomputer follow-up adds Nvidia GPUs

"Together we're building a foundation for next-generation computing architectures and AI-driven scientific discovery that advances the Genesis Mission goals."

This isn't the first MoU between RIKEN and ANL. The two research bodies signed another on AI for scientific research in 2024.

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RIKEN is already working with Fujitsu and Nvidia on the successor to Japan's Fugaku supercomputer, formerly the [12]most powerful computer in the world until the introduction of the [13]first exascale systems .

Codenamed "FugakuNEXT," this will be another system built with processors based on Arm cores, with Fujitsu [14]winning the contract to develop it last year. Soon after, the Japanese tech corporation [15]signed a deal with Nvidia to supply GPU accelerators and help design the hardware to incorporate them into the supercomputer. ®

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[5] https://www.theregister.com/2025/11/25/trump_ai_genesis_mission/

[6] https://www.theregister.com/2025/12/22/europe_gets_serious_about_cutting/

[7] https://www.theregister.com/2025/12/19/doe_genesis_agreements/

[8] https://www.theregister.com/2025/12/11/doe_genesis_mission_funding/

[9] https://www.theregister.com/2025/11/25/trump_ai_genesis_mission/

[10] https://www.theregister.com/2025/08/22/fugakunext_riken_nvidia_gpus/

[11] https://pubads.g.doubleclick.net/gampad/jump?co=1&iu=/6978/reg_onprem/hpc&sz=300x50%7C300x100%7C300x250%7C300x251%7C300x252%7C300x600%7C300x601&tile=3&c=33aXjvQtVzn-LdNQvyUi-8GQAAAwE&t=ct%3Dns%26unitnum%3D3%26raptor%3Deagle%26pos%3Dmid%26test%3D0

[12] https://www.theregister.com/2020/06/22/japan_arm_supercomputer_fugaku/

[13] https://www.theregister.com/2022/05/30/us_frontier_supercomputer_ousts_japans/

[14] https://www.theregister.com/2025/06/19/japan_fugakunext_fujitsu/

[15] https://www.theregister.com/2025/08/22/fugakunext_riken_nvidia_gpus/

[16] https://whitepapers.theregister.com/